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The biosimilar manufacturer must demonstrate that their version has no clinically meaningful differences in safety, purity, and potency not just pharmacokinetic equivalence, but a full analytical, clinical, and immunogenicity package

The NOEL was therefore 120 mg/kg in the diet (equivalent to 3 mg/kg body weight per day)

Vegetarianism and vitamin B-12 (cobalamin) deficiency

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

High serum levels of cholesterol increase antitumor functions of nature killer cells and reduce growth of liver tumors in mice

The 16-week dose-escalation schedule (starting at 0.25 mg and increasing to the maintenance dose of 2.4 mg once weekly) has only been validated in patients aged 12 and older