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These forces, known as shear stress, are detected by endothelial cells, triggering intracellular signaling cascades that are essential for regulating vascular physiology[92]

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Other possible side effects include abdominal pain and fatigue

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In a separate study in adult patients, FARXIGA provided additional benefit of SBP reduction as an add-on to metformin at 1 year (exploratory endpoint) 1,4 Primary Endpoint: 0.5% mean reduction in A1C from BL (n=400

Third, we selected strong IVs according to F-statistics (F= 2 /SE 2 )