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More importantly, co-delivery can produce synergistic effects- the combined efficacy is greater than each component alone- by synchronizing their bioavailability (89)

Additionally, LKB1 influences TERT expression through histone lactylation, promoting cellular senescence and telomerase regulation in NSCLC cells [53]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Unoki-Kubota H., Yamagishi S., Takeuchi M., Bujo H., Saito Y

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The clinical development program was discontinued due to insufficient weight loss efficacy rather than safety concerns