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Semaglutide is a single GLP-1 receptor agonist, Tirzepatide is a dual GLP-1/GIP agonist, and Retatrutide is a triple GLP-1/GIP/glucagon agonist

Within-class differences further inform selection, as GLP-1RAs are more strongly associated with reductions in atherosclerotic events, while SGLT2is demonstrate greater benefit in HF and kidney outcomes, with modest blood pressure-lowering effects that may contribute to cardiovascular risk reduction [9]

The current formulary-driven switch, in contrast, represents a payer-initiated formulary shift rather than a supply-side limitation

Indicators of kidney damage include: Less frequent urination Fatigue Shortness of breath Nausea Chest Pain Kidney damage can have serious long-term effects on a person

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More common during dose escalation