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The discovery of LSECs as the 'gatekeepers' is fascinating

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On the other hand, the annual eGFR decline was not significantly changed by the addition of SGLT2i to the GLP1Ra-preceding group (2.0 10.9 mL/min/1.73 m 2 /year to 1.8 5.4 mL/min/1.73 m 2 /year, p = 0.83)

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Butyrate promotes the intestinal immune system, protects intestinal epithelium integrity, inhibits tumor cell growth, and provides many other health benefits, and reduces cancer-promoting enzyme activity in the body, thereby reducing intestinal inflammation and colorectal cancer by protecting the intestinal wall (43)