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Furthermore, iron overload triggers an oxidative stress cascade that disrupts intestinal immune homeostasis and barrier function in mammalian hosts, leading to gut microbiota dysbiosis characterized by decreased abundance of probiotics (Gu et al., 2023

No changes to this codes description or status were made in recent annual updates

Regulatory positioning matters

Dietary Changes : Some families report benefits from gluten-free or casein-free diets, which may help reduce behavioral challenges

The clinical phenotype is variable and has been classified into neonatal onset forms, with the most severely affected patients presenting with congenital anomalies (Type I) or without anomalies (Type II), and mild and/or later onset (Type III) [138]

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