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In the computational study, no support was found for the hypothesis that a water molecule could serve as an alternative to Tyr9 as a proton donor ( 1 loss of binding energy due to the absence of the glycine residue

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Most discontinuations were due to gastrointestinal complaints

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Route of Administration How a peptide is delivered dramatically affects how long it stays in the body: Subcutaneous injection : slower absorption, longer duration Intramuscular injection : faster peak concentration, moderate duration Oral and intranasal peptides : often rapidly broken down, requiring protective technologies or higher doses For example, oral BPC-157 may work primarily through gut-localized pathways, while injectable versions may provide broader systemic benefits