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MR-Egger regression indicated no significant horizontal pleiotropy (Supplementary Table S6), supporting the validity of our primary findings

Dynamics of CNS barriers: evolution, differentiation, and modulation

J Clin Invest 2023;133:e167700.ArticlePubMedPMC 31

Weight loss rates on Retatrutide vary significantly based on starting weight, age, sex, metabolic rate, adherence level, and factors we do not fully understand yet

The full model was comprised of patient age, race/ethnicity, diabetes type (type 1 or 2), body mass index, HbA 1c , estimated glomerular filtration rate (eGFR), any hospitalization in the past year, any emergency department visit in the past year, severe hypoglycemic event in the past year, retinopathy, cardiovascular disease, depression, heart failure, insulin, metformin, and number of classes of glucose-lowering medications