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In a clinical study conducted by Stracquadanio et al., continuous administration of myo-inositol, gymnemic acid, and L-methylfolate for 6 months demonstrated substantial beneficial effects in PCOS patients, including improvement in menstrual cycle regularity and metabolic parameters, reduction in BMI and total testosterone, and increased insulin sensitivity (229)

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This modulatory effect appears to be adaptive

There is one more mechanistic thread worth naming because it is often invoked loosely: the copper itself