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18.3 Storage After First Use (Opened Pens or Bottles) After initial use, storage conditions may vary: Room temperature storage for limited duration Continued refrigeration depending on manufacturer guidance 18.4 Handling During Transportation Temperature excursions should be minimized during transport

However, due to the higher cost for the DPP-4 inhibitors, compared to sulfonylureas and thiazolidinediones, and the lack of long-term studies, it took several years for agencies responsible for guidelines to place DPP-4 inhibitors as a suggested glucose-lowering agent

Seo H, Park SJ, Song M