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Favorable Safety and Tolerability Profile : Across available studies, AOD-9604 has shown a favorable safety profile with no significant adverse hormonal or metabolic effects observed at experimental doses

A positive logRR indicated that the antioxidant group had a higher rate of side effects, while a negative value indicated higher rates in the placebo group

Approaches based on blocking proinflammatory mediators or neurotrophin activity have been shown to hamper neuronal ingrowth into the disc

Recruitment for ME/CFS patients started just before COVID related restrictions were introduced and research was suspended: one patient and one healthy control were recruited in February 2020, others from February 2021

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