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Upon activation, NF-B drives macrophage polarization toward the M1 (pro-inflammatory) phenotype, leading to the robust secretion of pro-inflammatory cytokines such as IL-1, IL-6, IL-12, and TNF- [109]

doi: 10.1016/j.bbrc.2015.01.098 184 SpielmanLJGibsonDLKlegerisA

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