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Ketamine administered for 3 days at higher doses increases apoptosis of rat hippocampal CA1 and dentate gyrus cells by suppressing phosphorylated-prkcg, phosphorylated-ERK1/2 and Bcl-2 expression and at postnatal day 7, high dose ketamine produced learning and memory impairments into adulthood (Galeotti et al., 2006)
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doi: 10.1021/acs.jmedchem.5b00726 10 JensenLHellebergHRoffelAvan LierJJBjrnsdottirIPedersenPJet al
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