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However, further studies are needed to optimise dosing, clarify sex-specific mechanisms, and confirm long-term safety and efficacy in large-scale clinical trials

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Nature , 643 (8071), 519528
A multicenter, randomized, open-label, phase 3b trial, SURMOUNT-5 was launched to compare the efficacy and safety of tirzepatide compared with semaglutide in adults with obesity or overweight without diabetes and at least 1 of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease