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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

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Treatment with 30 g/kg AC3174, an exenatide analog, administered via an osmotic pump for 28 days in Lep ob mice on a high trans -fat diet significantly reduced liver weight, hepatic lipid accumulation, and plasma alanine transaminase levels in comparison with pair-fed, weight-matched controls (30)

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doi: 10.1016/j.exer.2016.12.008 173 VogtASArsiwalaTMohsenMVogelMManolovaVBachmannMF