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This arrangement creates a hydrophobic surface on DII formed by residues Y402, L404, V407 and L443 against which the helix is held by orienting a hydrophobic side formed by residues L97, L101 and I104 towards DII

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Particularly in bladder cancer, alterations in mitochondrial dynamics are not only associated with the migratory and invasive abilities of tumor cells but also likely serve as key driving factors for tumor cell metastasis from the primary site to other tissues

At a subcellular level, toxins in cigarette smoke, such as cadmium and acrolein, are known to induce mitochondrial dysfunction and increase oxidative stress

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