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These advantages should be taken into account by clinicians when choosing anti-obesity treatments for patients with metabolic syndromes, particularly when skeletal status is a factor

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Since the presence of NAFLD is associated with a worse prognosis, as well as the occurrence of cardiovascular events [33], future therapeutic strategies should encompass the modulation of NAFLD

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These include the nitric oxide (NO) signaling system, angiogenic responses via VEGFR2, and antioxidant defense mechanisms involving HO-1 and other key enzymes (Jzwiak et al

Conclusions To summarize, long-acting GLP-1 RAs outshine older therapies by combining robust glucose control with meaningful weight loss in adults living with T2DM