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[127] Emerging data from the STEP UP trial, reported in January 2025, tested higher-dose semaglutide at 7.2 mg weekly in obese adults without diabetes, achieving a mean 20.7% weight reduction over 68 weeks, superior to 2.4 mg (15.3%) and placebo (2.6%), with comparable tolerability

This interaction triggers c-Met phosphorylation and activates downstream signaling cascades including the PI3K/AKT and MAPK/ERK pathways, which are fundamental to neuronal survival, dendritic arborization, and synapse formation