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(13) RANKL promotes osteoclast formation and activity, whereas OPG acts as a decoy receptor, inhibiting this process and protecting against bone loss

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The authors concluded that co-administration of T3 and DHA enhances the capacity of liver for the resolution of inflammation by increasing RVD1 and RVD2 availability, so such co-administration constitutes an important hepatoprotective protocol for clinical purposes (118)

doi:10.1042/bj0790516

While these observational findings do not prove causation, they have prompted multiple prospective clinical trials investigating semaglutide specifically for neurodegenerative conditions

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