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This indicates large doses (20- 30 billion) do not provide additional benefit beyond moderate doses containing several billion bacteria

The hypothesis suggests that PCs activate the S100A11/RAGE/PPAR signaling pathway, resulting in reduced RAGE expression and alleviation of cardiac fibrosis triggered by AGEs in type 2 diabetic rats (Luan et al., 2014)

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In fact, the depletion of this coenzyme was observed in the liver of our experimental model (Lorza-Gil et al., unpublished data ) as well as in skeletal muscle, heart, brain, plasma, HepG2 and insulin-secreting INS-1 cells after statins treatments (Tavintharan et al., 2007

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