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The once-weekly treatment is approved for adults with type 2 diabetes to improve blood sugar control, in combination with diet and exercise

Acylated iridoids with cytotoxicity from

However, simply showing that the enzyme can cleave a substrate in vitro does not necessarily mean that DPP-4 plays an important physiological role in regulating concentrations and/or modulating biological activity of the endogenous molecules, particularly in humans and, for many of these putative substrates, there is little, if any experimental evidence to show that DPP-4 does actually cleave them in vivo and/or whether this has any physiological consequence

10.1016/j.cell.2013.12.010 63 YaoX.XieR.CaoY.TangJ.MenY.PengH.et al (2021)

By the age of 60, the level drops to 80 ug/ml

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