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As of April 2025, the FDA had received 520 adverse event reports related to compounded semaglutide and 480 reports concerning compounded tirzepatide

But Amgen's MartiTide also was effective in a small, early-stage study

Insulin and glucagon-like peptide 1 receptor agonist combination therapy in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

However, they do not contain any medications that are proven to cause weight loss

The FDA-approved, branded versions of GLP-1 products were so popular that the brand manufacturers were not able to keep up with demand, prompting the FDA to declare a shortage for each of the semaglutide and tirzepatide products over the course of 2022