The most common GLP-1 side effects include: Nausea Diarrhea Vomiting Constipation Stomach pain A study from researchers at Mayo Clinic, presented in 2023, found that half of adults taking semaglutide, the active ingredient in Ozempic and Wegovy, experienced side effects, the most reported ones being nausea (38 percent) and diarrhea (9 percent)
It's now available in pill form for both type 2 diabetes (originally called Rybelsus, but now known as Ozempic pill) and weight loss (a Wegovy pill approved in 2025)
Maximum dose: 2 mg once weekly is the maximum dosage of Ozempic
Source: Medifast
As you lose weight on semaglutide, your heartburn may actually get better
Currently, allodynia is not listed as an adverse effect in the FDA-approved prescribing information for semaglutide products (Ozempic, Wegovy, and Rybelsus)