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It has also been reported to ameliorate the effects of reactive oxygen species (ROS) and free radical-induced oxidative stress (OS) and minimizing pathological disorders of sperm, like adenosine triphosphate (ATP) depletion leading to insufficient axonemal phosphorylation, lipid peroxidation as well as loss of motility and viability [9, 10]

However, lignans such as schisandrin A, schisandrin, gomisin A, gomisin C and schisanhenol often exhibit poor water solubility and undergo extensive first-pass metabolism, resulting in low systemic bioavailability

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