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JAMA 318(15):14601470 Nauck MA, Petrie JR, Sesti G, Mannucci E, Courrges JP, Lindegaard ML, Jensen CB, Atkin SL (2016) A phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes

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GLP-1 receptor activation Reduces appetite via central signaling, slows gastric emptying, increases glucose-dependent insulin secretion, and suppresses glucagon during hyperglycemia

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