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Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)

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Unraveling the hydroxypropionaldehyde (HPA) system: an active antimicrobial agent against human pathogens

Immunohistochemistry has been used to show decreased expression of zonula occludens-1 in cerebral capillaries and increased leakage of perivascular immunoglobulin G from the blood, which indicates increased permeability in diabetes [21]

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Pairing it with Vitamin C enhances its efficacy, as Vitamin C helps regenerate oxidized glutathione back to its active form