An important study published in the Annals of Clinical Endocrinology and Metabolism found that patients with Hashimoto thyroiditis have altered GLP-1 and GLP-2 serum levels compared to healthy controls
Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1 (7-36) amide degradation in type 2 diabetic subjects
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As these therapies move into broader use, addressing these real-world complexities will be essential to realizing their full potential
The genetic variants, carried by roughly 10% of the general population, cause a surprising and still mysterious phenomenon that researchers refer to as GLP-1 resistance, in which levels of the hormone GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar, are higher but less biologically effective
6 These hormones are secreted into the intestines in response to the ingestion of a meal