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This means that unlike simply being in a calorie deficit where you risk losing muscle, glucagon receptor activation is associated with increased energy expenditure pathways in muscle, and ongoing research is evaluating potential body-composition differences compared with GLP-1only compounds

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In contrast, older individuals ( 65 years) exhibited minimal risk reduction (HR = 0.88), potentially due to advanced endothelial dysfunction and reduced metabolic flexibility, limiting the effectiveness of SGLT2 inhibitors in preventing long-term complications [49]

By aligning lifestyle support with medical therapy, patients see not only better resultsbut more sustainable ones

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