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Mechanism of activation of mechanistic target of rapamycin complex 1 by methionine

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To date, few radiosensitising drugs have been approved for use clinically ( in vitro and ex vivo models of oesophageal adenocarcinoma ( Metformin is a clinically approved drug used for the management of type II diabetes ( This study demonstrates, through real-time live cell metabolic profiling and transcriptomic profiling, that metformin significantly alters energy metabolism in both in vitro and ex vivo models of rectal adenocarcinoma and importantly, radiosensitises radioresistant rectal cancer cells to clinically-relevant doses of X-ray radiation

The focus is a concrete documentation change that improves traceability and supports reproducible recordkeeping for lawful laboratory developmental research procurement