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Among these four isoforms, AK1C2 and AK1C3 share 87.9% amino acid sequence identity and both enzymes possess 3-hydroxysteroid dehydrogenase (3-HSD) activity and catalyze 5-dihydrotesterone reduction to produce 5-androstane-3,17-diol (3-diol) 30

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Functional group analysis DAVID 6.7 (Database for Annotation, Visualization, and Integrated Discovery), a functional annotation tool, was used to analyze differentially expressed genes

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Synthesis of 3-(4-(pyridin-2-yldiazenyl)phenoxy)propan-1-ol (compound 2) The 3-(4-(pyridin-2-yldiazenyl)phenoxy)propan-1-ol was synthetized using a similar procedure as previously reported 46