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Six-week-old male C57BL/6 J mice were purchased from Taiwan National Laboratory Animal Center

15,226,227 Recent therapeutic approaches focus on aldose reductase inhibitors (ARIs), such as epalrestat and ranirestat, which have shown promise in reducing sorbitol accumulation and ameliorating neuropathic symptoms in clinical trials

(1991), mitochondria were obtained from fresh kidney cortical tissue by homogenization and differential centrifugation

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