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Within the lung tumor microenvironment, CPT1Aa master regulator of fatty acid -oxidationcooperates with macrophage-derived L-carnitine to orchestrate a dual outcome: conferring resistance to ferroptosis while simultaneously impairing the antitumor function of CD8 + T lymphocytes ( Structurally characterized by up to four BCL-2 homology (BH) domains that govern protein interactions, the BCL-2 protein family is divided into three functionally opposing categories: multi-domain pro-survival members (e.g., BCL-2, BCL-XL, MCL-1), which inhibit apoptosis by sequestering BH3-only initiators (such as BIM, PUMA) and multi-domain effectors (BAX/BAK)

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All mice were housed in standard mouse cages under a 12-h dark/12-h light cycle and constant temperature ( ~ 25 C) and humidity ( ~ 55%)

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Crit Rev Food Sci Nutr 64:35023521

doi: 10.1016/j.cellsig.2024.111328 28 WangBWangYZhangJHuCJiangJLiYet al