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2 Current management of NTHi infections necessitates alternative therapeutic strategies 2.1 Antibiotic therapy NTHi-associated lower respiratory infections are typically treated with moderate spectrum -lactam (typically amoxicillin or amoxicillin-clavulanic acid) antibiotics (Marchant et al., 2024)

Evidence for this action has been demonstrated in mice (Fridolf et al., 1991), rats (de Heer et al., 2008), dogs (Freyse et al., 1997), and humans in vivo (Hare et al., 2009), as well as in intact isolated mouse islets (De Marinis et al., 2010)

Gstt1 is expressed in latent disseminated tumour cells (DTCs), is retained within a subpopulation of slow-cycling cells within existing metastases, and its inhibition leads to complete regression of macrometastatic tumours

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Early animal studies suggest it may help repair damaged tissue throughout the body

Viknesh, C., Kumar, P., Seetharaman, R