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Epithalon and sleep enhancement As noted, epithalon can increase levels of melatonin, which is strongly involved in regulating the sleep cycle, thus leading to research interest in the sleep-promoting effect of epithalon [8]

Contraindications include Lebers hereditary optic neuropathy, severe kidney disease, known cobalt or cobalamin allergy, and polycythemia vera

Its typically used in short 1020 day cycles once or twice a year, depending on individual health goals and age

J Orthop Res 2003

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C max was also similar in the renal impairment groups versus the normal renal function group