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Obesity, insulin resistance, and aging increase NNMT expression, making its suppression crucial to metabolic dysfunction

Scar tissue or lipohypertrophy areas should be avoided

A reticulocyte count may also be checked, as a rise in reticulocytes (young red blood cells) within the first week indicates effective bone marrow response

In Phase 2 trial imaging, fat mass fell substantially more than lean mass, so most of the weight lost was fat the muscle loss is real but is a minority of total loss and is in the same range as semaglutide and tirzepatide

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