This master antioxidant plays a vital role in nutrient metabolism, antioxidant defence, and regulation of cellular activities such as protein synthesis and immune response
The translational value of targeting cuproptosis and copper metabolism lies in the identification of key regulatory molecules (e.g., FDX1, DLAT, ATP7A/B) and potential biomarkers (e.g., serum CP and NCC) that could guide clinical decision-making
For instance, acetaminophen (Tylenol) lowers glutathione levels as the liver uses its stores to metabolize this drug
Targeting glutamate metabolism specifically eliminates cisplatin-resistant cells [47]
Table 1 Key enzymes/transporters and their drugs in cancer amino acid metabolism
"If you're serious about nutritional supplements and are dedicated to improving lives," said Nature's Sunshine Chief Executive Officer, Terrence Moorehead, "then you have to make your own products