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Similarly, mucoadhesive microcarriers have been shown to prolong intestinal residence time, further augmenting the anti-inflammatory effects of oral probiotics 225

DAMPs released from dead adipocytes in obesity activate macrophage MINCLE, which induces myofibroblast production and promotes fibrotic gene expression [219]

Figure 5 The Asc-GSH cycle is operating in various cellular compartments including the cytosol, mitochondria, chloroplast, and peroxisomes

Recognising these interconnected symptoms enables timely intervention before deficiency leads to permanent damage

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