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According to StatPearls (NCBI Bookshelf), the most common adverse effect of intramuscular vitamin B12 injections is significant pain at the injection site, which is particularly noted in thinner individuals

The hydrogenases and, by necessity, enzymes associated with cobalt utilization, involve metal-carbon bonds

Regarding the mentioned studies, it seems that a higher dosage of folic acid especially in combination with B6 and B12 could alleviate the symptoms of migraine

So, injections are a more direct way to make sure your body gets the B12 it needs, while tablets might not work as efficiently because they have to go through your stomach and intestines first

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