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Localized (Intra-Articular Injection): For joint-specific injuries like a meniscus tear, some research protocols involve injecting the compound directly into the joint capsule

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long-term safety and efficacy in humans have not been fully established

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The population heterogeneity, various Se formulations and the length of Se supplementation, as well as different thyroid function test and Se measurement strategies, are among the reasons for the study conclusions inconsistency (244)