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These drugs, like GLP-1 agonists, aim to decrease food intake and improve blood glucose regulation

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It can also induce ER stress by inducing hyperglycemia, making AGEs, non-esterified fatty acids (NEFA) and other nutrients surplus, thereby directly inducing ER stress (Incalza et al

10.1016/j.cgh.2015.02.019

The regulatory answer is more layered than a simple yes or no, and it shifted in 2026