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This reluctance may have several causes, including: The feeling that they are doing wellenough in managing their diabetes and do not want to make a change even if it may improve outcomes Concern that GI AEs may return Not wanting to change a routine that they see as working for them The change in device may be a barrier
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doi:10.1021/acs.jafc.9b05383 256
Subcutaneous administration bypasses intestinal conversion to trimethylamine-N-oxide (TMAO), a metabolite associated with cardiovascular concerns [4] , while providing 100% bioavailability compared to 518% for large oral doses [3]
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A more serious concern with long term GLP-1RA usage relates to the potential increased risk for PDAC due to promoting cellular proliferation
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