Br J Dermatol 169 (4): 804-11, 2013
Every time we eat, GLP-1 is released in the body to help regulate blood sugar levels and trigger the pancreas to release insulin
Note: animal studies indicate that high doses of DPP-4 inhibitors & GLP-1 agonists cause expansion of cells of the pancreatic ductal glands and can cause premalignant pancreatic intraepithelial lesions (PanIN) that have the potential to progress to pancreatic adenocarcinoma
GLP-1 receptor agonists are shifting healthcare from: glucose control to whole-body metabolic disease modification. The future of endocrinology will likely be built around: precision metabolic medicine, multi-agonist therapies, oral incretin platforms, and integrated cardiometabolic care
A small amount of redness immediately after injection is normal
While the company was disappointed by the rejection, Applied CEO Soshana Shendelman said in a statement that it plans to work with the FDA to address concerns in the CRL and determine an expeditious path forward for govorestat