Evaluation of Acute Toxicity and the Effect of Single Injected Doses of Zerumbone on the Kidney and Liver Functions in Sprague Dawley Rats
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The proposed mechanisms are multifaceted
NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)