Weight-dependent and independent effects of semaglutide in participants with MASH: Secondary analysis of the phase 3 ESSENCE trial The ESSENCE trial is a worldwide clinical study assessing whether semaglutide, one of the most well known GLP-1 medications, works for people who have MASH
Dehydration and reduced oral intake commonly occur with GLP-1 receptor agonists due to their effects on appetite suppression and gastrointestinal motility
Related Reading Tirzepatide Vs Semaglutide Side Effects Wegovy Side Effects Semaglutide Side Effects Mounjaro Side Effects Plexusdx Pricing and availability current as of June 2026
Limitations This study has several limitations that should be acknowledged
Short-acting GLP-1 drugs, for instance, may have to be stopped 2 to 4 weeks prior to surgery
[DOI] [PubMed] [Google Scholar] 46.Mann JFE, Fonseca V, Mosenzon O, et al