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GCL is considered the speed limiting enzyme of synthesis since overexpression of GS does not increase GSH levels while overexpression of GCL increases the synthesis of GSH (61) (Figure 3)
In a placebo-controlled trial in 80 women with PCOS preparing for IVF, 1,800 mg NAC per day for six weeks appeared to improve the quality of oocytes
These studies have shown that GC ferroptosis promotes PCOS development
10.3390/cells12010090 153 SuzukiS.VenkateshD.KandaH.NakayamaA.HosokawaH.LeeE.et al (2022)
All the procedures in this study related to animal handling, care, and the treatment were performed according to guidelines approved by the IACUC of Pharmaron following the guidance of the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)