Comprehensive toxicology studies found no lethal dose even at extremely high levels (20 mg/kg intramuscularly in rats, equivalent to approximately 1,400 mg for a 155 pound human)
Notably, CT-388's weight loss curve had not plateaued at 48 weeks, suggesting the final treatment effect could be even higher at 72 weeks in the Phase III program
Seek medical advice if you miss three consecutive periods, experience severe symptoms, or have concerns about fertility or bone health
These lipidation and amino acid substitutions solve two fundamental problems with native human amylin: its extremely short plasma half-life (measured in minutes) and its well-documented tendency toward amyloid fibril formation
Achieving and maintaining a steady weight before surgery can also minimize potential complications, promoting a smoother recovery and more sustainable outcomes
It can result in a natural skin lightening effect