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Gen Comp Endocrinol (2003) 134(3):2208.10.1016/S0016-6480(03)00281-8 10 PierantoniRCobellisGMeccarielloRFasanoS

Topical Numbing Cream: Some clinics apply a numbing cream to minimize discomfort during the injection

Optimizing the structure of the substrate such as making it porous or arrayed to make the interface bulk contact could also improve the interface-related operational stability

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The expanded approval was based on data from the Phase III EoE KIDS trial, where 66% of children who received the higher dose Dupixent at tiered dosing regimens experienced histological disease remission after 16 weeks of treatment, compared to just 3% in the placebo group, per the press release