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Ergothioneine levels are typically low in the commonly consumed commercial button mushroom species prevalent in Western diets, such as Agaricus bisporus

We demonstrate a host of novel neurochemical abnormalities consistent with schizophrenia-like phenotypes and our observed cognitive and electrophysiological cortical alterations

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This means it wont break down and become ineffective if exposed to air

2021;13 doi: 10.1126/scitranslmed.abd6469