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There is no rebate for the big pharmaceutical companies or the big insurance companies on testosterone

This means very small amounts may have strong biological effects

Some vendors sell oral peptides, but the bioavailability is extremely low compared to injection

They chose peptide therapy and went looking for it, which means they had higher baseline expectations of intervention efficacy

Interaction with H1/3 revealed 14 docking solutions at site 5, the DNA-binding domain, where the peptide bound with a minimum energy of 56.49 kcal/mol using the sequence His-Pro-Ser-Tyr-Met-Ala-His-Pro-Ala-Arg-Lys

These studies help characterize the in vivo consequences of NNMT inhibition and inform further mechanistic research