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First, melatonin appears most useful where oxidative load is high (e.g., PCOS, diminished ovarian reserve, repeat-poor response), aiming to improve oocyte/embryo competence rather than to replace first-line ovulation-induction strategies

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348 The role of the UPS in NDDs The ubiquitinproteasome system (UPS) represents a highly coordinated protein quality-control network responsible for selectively tagging, recognizing, and degrading damaged, misfolded, or excess proteins through ubiquitination

These medications bind to their respective receptors throughout the body, particularly in the pancreas, brain, and gastrointestinal tract